Fred DeStefano (April 4, 1900 – June 27, 1974) was an American professional football player who was a running back for two seasons for the Chicago Cardinals. After retiring from football, he became a physician, and died in Houston, Texas in 1974 of multiple organ failure.Ancestry.com. Texas, Death Certificates, 1903–1982 [database on-line]. Provo, UT, USA: Ancestry.com Operations, Inc., 2013
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