Esdaile is a surname. Notable people with the surname include:
Arundell Esdaile (1880–1956), British librarian, Secretary to the British Museum, 1926-40 James Esdaile (1808–1859), surgeon and mesmerist James Esdaile (mayor) (1714–1793), Lord Mayor of London, 1777 James Esdaile (minister) (1775–1854), Scottish minister and writer Katharine Esdaile (1881–1950), British art historian Nicole Esdaile (born 1987), Australian goalball player William Esdaile (1758–1837), English banker
Places Esdaile, Wisconsin
Other Esdaile state, an extreme procedure in hypnosis