Ghesquière is a surname. Notable people with the surname include:
Nicolas Ghesquière (born 1971), French fashion designer, creative director for Louis Vuitton Régis Ghesquière (1949–2015), Belgian decathlete Geoffrey Ghesquière (born 1989), Belgian footballer Ferdinand Ghesquière (1933–2021), Belgian politician, member of the Chamber of Representatives and the Senate Kris Ghesquière (born 1973), Belgian art dealer and designer, founder of Composition Gallery
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