Diego Ruiz may refer to:
Diego Ruiz (skier) (born 1977), Spanish cross-country skier Diego Ruiz (footballer) (born 1980), Argentine footballer Diego Ruiz (runner) (born 1982), Spanish middle-distance runner Diego Ruiz de Montoya (1562–1632), Spanish Jesuit theologian Diego Ruiz Ortiz (1532–1571), Augustinian missionary and martyr in Peru Diego Ruiz Restrepo (born 1990), Colombian serial killer in Chile Quas (video gamer) or Diego Ruiz