Charles or Charlie Murphy may refer to:
Politics Charles Murphy (1880–1958), Irish politician more commonly referred to as Cathal Ó Murchadha Charles Murphy (Australian politician) (1909–1997), member of the Victorian Legislative Assembly Charles Murphy (Canadian politician) (1862–1935), member from Russell in the Canadian House of Commons 1908–1925 and senator 1925–1935 Charles A. Murphy (born 1965), Massachusetts representative from the 21st District Charles Frederick Murphy (1875–1934), New York politician Charles Francis Murphy (1858–1924), American political figure who was leader of Tammany Hall 1902–1924 Charles S. Murphy (1909–1983), White House counsel during the Truman Administration 1951–1953 Terrence Murphy (Canadian politician) (Charles Terrence Murphy, 1926–2008), member from Sault Ste. Marie in the Canadian House of Commons 1968–1972
Sports Charles Minthorn Murphy (1870–1950), American cyclist, known as "Mile-a-Minute Murphy" Charles M. Murphy (coach) (1913–1999), American football, basketball, and baseball player and coach Stretch Murphy (Charles C. Murphy, 1907–1992), All-American basketball player at Purdue University Charles Murphy (baseball owner) (1868–1931), baseball executive and sportswriter Charles Murphy (pitcher), American Negro leagues baseball player
Arts and entertainment Charlie Murphy (actor) (1959–2017), American writer, actor, and stand-up comedian Charlie Murphy (artist), artist based in London, UK Charlie Murphy (singer-songwriter) (1953–2016), American singer-songwriter Charlie Murphy (actress) (born 1988), Irish actress Chuck Murphy (singer) (born 1955), American singer, songwriter, and musician
Other Charles Murphy (architect) (1890–1985), American architect Charles M. Murphy (priest), Catholic priest, former rector of the Pontifical North American College Charles B. G. Murphy (1906–1977), pioneer and philanthropist in psychiatry Chuck Murphy (bishop) (1947–2018), American Anglican bishop Charles Murphy (hedge fund manager) (1961–2017), American hedge fund manager Charles J. V. Murphy (1904–1987), American journalist and author