Mary Hughes (1874–1958) was the second wife of Billy Hughes, Prime Minister of Australia.
Mary Hughes may also refer to:
Mary Hughes (bowls), lawn bowls competitor for Wales Mary Hughes (British author), British author and teacher Mary Hughes (social worker) (1860–1941), British social worker Mary Beth Hughes (1919–1995), American actress Mary Caroline Hughes (1862–1916), English geologist, artist and photographer Mary Vivian Hughes (1866–1956), British author and educator
See also Hughes (surname)