William Pierce may refer to:
Politics William Pierce (Georgia politician) (1753–1789), Continental Congressman from Georgia William Pierce (Illinois politician), Illinois state representative William Luther Pierce (1933–2002), white nationalist and political activist Bud Pierce (William C. Pierce, born 1956), politician in Oregon
Sports Billy Pierce (Walter William Pierce, 1927–2015), American baseball player Bill Pierce (baseball) (William Herbert Pierce, 1890–1962), Negro leagues baseball player and manager
Other William Pierce (serial killer) (1931–2020), American serial killer also known as "Junior" William Henry Pierce (missionary) (1856–1948), Canadian missionary for the Methodist church William H. Pierce (1859–1939), American mortuarist William S. Pierce (born 1937), American surgeon and chemical engineer William Pierce (robber), perpetrator of the Great Gold Robbery
See also Bill Pierce (disambiguation) Pierce (surname) William Pearce (disambiguation) William Peirce (disambiguation)