The concept of the Antichrist has been a vigorous one throughout Christian history, and there are many references to it and to associated concepts both in the Bible and in subsequent ecclesiastical writings.

New Testament The words antichrist and antichrists appear four times in the First and Second Epistle of John. 1 John chapter 2 refers to many antichrists present at the time while warning of one Antichrist that is coming.A Scriptural and Historical Survey of the Doctrine of the Antichrist by John Brug, p. 1 The "many antichrists" belong to the same spirit as that of the one Antichrist. John wrote that such antichrists deny "that Jesus is the Christ", "the Father and the Son", and would "not confess Jesus came in the flesh."

Related terms Many commentators, both ancient and modern, identify the Man of Sin in 2 Thessalonians chapter 2 as the Antichrist, even though they vary greatly in who they view the Antichrist to be.Schink, W.F. "The Scriptural Doctrine of the Antichrist." Our Great Heritage: Vol. 3 Ed. Lange, Lyle and Albrecht, Jerome G. Milwaukee: Northwestern Publishing house, 1991. p. 572. Paul provides greater detail than found in John's letters.A Scriptural and Historical Survey of the Doctrine of the Antichrist by John Brug, p. 2 He uses the term "Man of Sin" (sometimes translated son of perdition or man of lawlessness) to describe what John identifies as the Antichrist.

Paul writes that this Man of Sin will possess a number of characteristics. These include "sitting in the temple", opposing himself against anything that is worshiped, claiming divine authority, working all kinds of counterfeit miracles and signs, and doing all kinds of evil. Paul notes that "the mystery of lawlessness"Greek = "musterion anomias" (though not the Man of Sin himself) was working in secret already during his day and will continue to function until being destroyed on the Last Day. His identity is to be revealed after that which is restraining him is removed.

The term is also often applied to prophecies regarding a "Little horn" power in Daniel 7. For an example of one commentator that interprets Daniel 7 as referring to the Antichrist, see Kretzmann in his Popular Commentary on Daniel 7 Daniel 9:27 mentions an "abomination that causes desolations" setting itself up in a "wing" or a "pinnacle" of the temple. Some scholars interpret this as referring to the Antichrist.For example, Gawrisch in his Eschatological Prophecies and Current Misinterpretations, p. 14 Some commentators also view the verses prior to this as referring to the Antichrist.For example, Kretzmann in his Popular Commentary, on Daniel 9 Jesus references the abomination from Daniel 9:27, 11:31,Daniel and 12:11 in Matthew 24:15 and Mark 13:14Mark , see footnotes in Dr. Beck's An American Translation 4th ed. Leader Publishing: New Haven, Mo., 2000. when he warns about the destruction of Jerusalem. Daniel 11:36-37 speaks of a self exalting king, considered by some to be the Antichrist.For example, Gawrisch in his Eschatological Prophecies and Current Misinterpretations, pp. 14 and 37. Also see Walter H. Roehrs and Martin H Franzmann, joint author, Concordia Self-Study Commentary, electronic ed. (St. Louis: Concordia Publishing House, 1998, c1979). 586.

Antiochus Epiphanes attempted to replace worship of Yahweh with veneration of himself, and was referred to in the Daniel 8:23-25 prophecy.Daniel 8:23-25 (NIV) and Kretzmann's Popular Commentary, Daniel 8 His command to worship false gods and desecration of the temple was seen by Jerome as prefiguring the Antichrist.See Jerome's Commentary on Daniel

Several American evangelical and fundamentalist theologians, including Cyrus Scofield, have identified the Antichrist as being in league with (or the same as) several figures in the Book of Revelation including the Dragon, the Beast, the False Prophet, and the Whore of Babylon.See footnotes in Revelation 7 and 13 in the Scofield Reference Bible, 1917

Early Church

Polycarp (69 – 155) warned the Philippians that everyone that preached false doctrine was an antichrist.Polycap's Letter to the Philippians, paragraph 7

Irenaeus (c. 125 – c. 202) held that Rome, the fourth prophetic kingdom, would end in a tenfold partition. The ten divisions of the empire are the "ten horns" of Daniel 7 and the "ten horns" in Revelation 17. A "little horn," which is to supplant three of Rome's ten divisions, is also the still future "eighth" in Revelation.

He identified the Antichrist with Paul's Man of Sin, Daniel's Little Horn, and John's Beast of Revelation 13.Article on the Antichrist: Signs of the Man of Sin - The Antichrist, by Frank Barnswick He sought to apply other expressions to Antichrist, such as "the abomination of desolation," mentioned by Christ (Matt. 24:15) and the "king of a most fierce countenance," in Gabriel's explanation of the Little Horn of Daniel 8.

Under the notion that the Antichrist, as a single individual, might be of Jewish origin, he fancies that the mention of "Dan," in Jeremiah 8:16, and the omission of that name from those tribes listed in Revelation 7, might indicate Antichrist's tribe. He also speculated that it was “very probable” the Antichrist might be called Lateinos, which is Greek for “Latin Man”.Against Heresies, Book 5, Chapter 30

Tertullian (c.160 – c. 220) held that the Roman Empire was the restraining force written about by Paul in 2 Thessalonians 2:7-8. The fall of Rome and the disintegration of the ten provinces of the Roman Empire into ten kingdoms were to make way for the Antichrist. 'For that day shall not come, unless indeed there first come a falling away,' he [Paul] means indeed of this present empire, 'and that man of sin be revealed,' that is to say, Antichrist, 'the son of perdition, who opposeth and exalteth himself above all that is called God or religion; so that he sitteth in the temple of God, affirming that he is God. Remember ye not, that when I was with you, I used to tell you these things? And now ye know what detaineth, that he might be revealed in his time. For the mystery of iniquity doth already work; only he who now hinders must hinder, until he be taken out of the way.' What obstacles is there but the Roman state, the falling away of which, by being scattered into the ten kingdoms, shall introduce Antichrist upon (its own ruins)? And then shall be revealed the wicked one, whom the Lord shall consume with the spirit of His mouth, and shall destroy with the brightness of His coming: even him whose coming is after the working of Satan, with all power, and signs, and lying wonders, and with all deceivableness of unrighteousness in them that perish.'

Hippolytus of Rome (c. 170 – c. 236) held that the Antichrist would come from the tribe of Dan and would rebuild the Jewish temple in order to reign from it. He identified the Antichrist with the Beast out of the Earth from the book of Revelation. By the beast, then, coming up out of the earth, he means the kingdom of Antichrist; and by the two horns he means him and the false prophet after him. And in speaking of “the horns being like a lamb,” he means that he will make himself like the Son of God, and set himself forward as king. And the terms, “he spake like a dragon,” mean that he is a deceiver, and not truthful.Hippolytus's Treatise on Christ and Antichrist, part 2

Origen (185–254) refuted Celsus's view of the Antichrist. Origen utilized Scriptural citations from Daniel, Paul, and the Gospels. He argued: Where is the absurdity, then, in holding that there exist among men, so to speak, two extremes-- the one of virtue, and the other of its opposite; so that the perfection of virtue dwells in the man who realizes the ideal given in Jesus, from whom there flowed to the human race so great a conversion, and healing, and amelioration, while the opposite extreme is in the man who embodies the notion of him that is named Antichrist?... one of these extremes, and the best of the two, should be styled the Son of God, on account of His pre-eminence; and the other, who is diametrically opposite, be termed the son of the wicked demon, and of Satan, and of the devil. And, in the next place, since evil is specially characterized by its diffusion, and attains its greatest height when it simulates the appearance of the good, for that reason are signs, and marvels, and lying miracles found to accompany evil, through the cooperation of its father the devil.

Post-Nicene Christianity

Athanasius (c. 293 – 373), writes that Arius of Alexandria is to be associated with the Antichrist, saying, “And ever since [the Council of Nicaea] has Arius's error been reckoned for a heresy more than ordinary, being known as Christ's foe, and harbinger of Antichrist.”from Athanasius' "Four Discourses"

John Chrysostom (c. 347–407) warned against speculations and old wives' tales about the Antichrist, saying, “Let us not therefore enquire into these things”. He preached that by knowing Paul's description of the Antichrist in 2 Thessalonians Christians would avoid deception.Chrysostom Homily 1 on the 2nd Epistle of St. Paul the Apostle to the Thessalonians

Jerome (c. 347–420) warned that those substituting false interpretations for the actual meaning of Scripture belonged to the “synagogue of the Antichrist”. “He that is not of Christ is of Antichrist,” he wrote to Pope Damasus I. He believed that “the mystery of iniquity” written about by Paul in 2 Thessalonians 2:7 was already in action when “every one chatters about his views.” To Jerome, the power restraining this mystery of iniquity was the Roman Empire, but as it fell this restraining force was removed. He warned a noble woman of Gaul: “He that letteth is taken out of the way, and yet we do not realize that Antichrist is near. Yes, Antichrist is near whom the Lord Jesus Christ “shall consume with the spirit of his mouth.” “Woe unto them,” he cries, “that are with child, and to them that give suck in those days.”... Savage tribes in countless numbers have overrun run all parts of Gaul. The whole country between the Alps and the Pyrenees, between the Rhine and the Ocean, has been laid waste by hordes of Quadi, Vandals, Sarmatians, Alans, Gepids, Herules, Saxons, Burgundians, Allemanni, and—alas! for the commonweal!–even Pannonians. In his Commentary on Daniel, he noted, “Let us not follow the opinion of some commentators and suppose him to be either the Devil or some demon, but rather, one of the human race, in whom Satan will wholly take up his residence in bodily form.” Instead of rebuilding the Jewish Temple to reign from, Jerome thought the Antichrist sat in God's Temple inasmuch as he made “himself out to be like God.” He refuted Porphyry's idea that the “little horn” mentioned in Daniel chapter 7 was Antiochus Epiphanes by noting that the “little horn” is defeated by an eternal, universal ruler, right before the final judgment. Instead, he advocated that the “little horn” was the Antichrist: We should therefore concur with the traditional interpretation of all the commentators of the Christian Church, that at the end of the world, when the Roman Empire is to be destroyed, there shall be ten kings who will partition the Roman world amongst themselves. Then an insignificant eleventh king will arise, who will overcome three of the ten kings... after they have been slain, the seven other kings also will bow their necks to the victor.

Circa 380, an apocalyptic pseudo-prophecy falsely attributed to the Tiburtine Sibyl describes Constantine as victorious over Gog and Magog. Later on, it predicts: