Rezek (feminine Rezková) is a Czech surname, a reference to person's red hair. Notable people include:
Antonín Rezek (1853–1909), Czech historian Francisco Rezek (born 1944), Brazilian judge Jakub Rezek (born 1998), Czech footballer Jan Rezek (born 1982), Czech footballer Miloslava Rezková (1950–2014), Czech high jumper Ron Rezek (born 1946), American entrepreneur