Stafford House is a mansion in the St. James's district in the West End of London.

Stafford House may also refer to:

in Canada Joseph Stafford House, listed on the Canadian Register of Historic Places

in the United Kingdom Stafford House International School, a language school in Canterbury, England Stafford House International School, a language school in London, England Stafford House International School, a language school in Cambridge, England Stafford House Study Holidays, English language summer camps run across the UK, USA and Malaysia Stafford House, Wrexham, building in Wrexham, Wales

in the United States Francis M. Stafford House, Paintsville, Kentucky Frederick H. and Elizabeth Stafford House, Port Hope, Michigan William R. Stafford House, Port Hope, Michigan Captain John H. Stafford House, Bronx, New York, a New York City Landmark John Stafford House, Columbus, Texas, formerly listed on the National Register of Historic Places