Le Guen is Breton surname, the word comes from gwenn, meaning white or blessed (figurative meaning) in Breton. Notable people with the surname include:
Gilles Le Guen (born 1955), French jihadist Jacques Le Guen (1958–2025), member of the National Assembly of France Jean-Marie Le Guen (born 1953), member of the National Assembly of France Paul Le Guen (born 1964), French former international football defender and coach
See also Saint-Guen Ursula K. Le Guin