Nijssen is a Dutch patronymic surname originating from the given name "Denijs" (Denis). People with this surname include:
Nijssen Han Nijssen (1935–2013), Dutch ichthyologist Sjir Nijssen (born 1938), Dutch computer scientist known for Nijssen's Information Analysis Method Tom Nijssen (born 1964), Dutch tennis player
Nyssen Hubert Nyssen (1925–2011), Belgian writer and publisher
See also De Nijs Nijs Nissen (surname)