Leysen is a surname. Notable people with the surname include:
André Leysen (1927–2015), Belgian businessman Bart Leysen (born 1969), Belgian cyclist Christian Leysen (born 1954), Belgian businessman Fedde Leysen (born 2003), Belgian footballer Johan Leysen (born 1950), Belgian actor Louis Leysen (1932–2009), Belgian international footballer Senne Leysen (born 1996), Belgian cyclist Thomas Leysen (born 1960), Belgian entrepreneur Tobe Leysen (born 2002), Belgian footballer