Coppini is a surname. Notable people with the surname include:
Aquilino Coppini (died 1629), Italian musician and lyricist Enzo Coppini (1920–2011), Italian racing cyclist Fausto Eliseo Coppini (1870–1945), Italian-Argentine painter Francesco Coppini, Bishop of Terni from 1458 to 1462 Germán Coppini (1961–2013), Spanish singer-songwriter Matteo Coppini (born 1989), Sammarinese footballer Pompeo Coppini (1870–1957), Italian-American sculptor