Destro (literally Right (opposite of left)) is an Italian surname. Notable people and fictional characters with the surname include:
People Elizabeth Destro, American film producer
Giustina Destro (born 1945), Italian politician and entrepreneur Mattia Destro (born 1991), Italian footballer Robert Destro, American attorney, academic, and government official
Fictional characters Destro, a fictional character in the G.I. Joe universe
See also