The Netherlands Football League Championship 1945–1946 was contested by 66 teams participating in six divisions. The national champion would be determined by a play-off featuring the winners of the eastern, northern, two southern and two western football divisions of the Netherlands. HFC Haarlem won this year's championship by beating AFC Ajax, sc Heerenveen, NAC, NEC Nijmegen and Limburgia.

New entrants Eerste Klasse East: Promoted from 2nd Division: Be Quick Zutphen Eerste Klasse North: Promoted from 2nd Division: LAC Frisia 1883 Eerste Klasse South-I: Moving in from the combined southern division from 1943-44: BVV Den Bosch, FC Eindhoven, LONGA, NAC, NOAD and Willem II Promoted from 2nd Division: Baronie/DNL, RBC Roosendaal, RKTVV Tilburg, VC Vlissingen & VV Helmond Eerste Klasse South-II: (new division) Moving in from the combined southern division from 1943-44: Juliana, Maurits, MVV Maastricht, PSV Eindhoven, RFC Roermond and De Spechten Promoted from 2nd Division: Bleijerheide, Brabantia, Limburgia, SC Emma & VVV Venlo Eerste Klasse West-I: Moving in from West-II: AFC Ajax, Emma, HVV 't Gooi, RFC Rotterdam and VSV Promoted from 2nd Division: DOS Eerste Klasse West-II: Moving in from West-I: DFC, DWS, HBS Craeyenhout, Sparta Rotterdam and Stormvogels Promoted from 2nd Division: SC Neptunus

Divisions

Eerste Klasse East

Eerste Klasse North

Eerste Klasse South-I

Transferred to South-II Team moving to Division South-II next season.

Play-off

NAC qualified for the Championship Play-off.

Eerste Klasse South-II

Eerste Klasse West-I

Eerste Klasse West-II

Championship play-off

References RSSSF Netherlands Football League Championships 1898-1954 RSSSF Eerste Klasse Oost RSSSF Eerste Klasse Noord RSSSF Eerste Klasse Zuid RSSSF Eerste Klasse West