Thomas Osborne, or variants thereof, may refer to:
England Thomas Osborne, 1st Duke of Leeds (1632–1712), English Lord High Treasurer, Lord President of the Council and MP for York Thomas Osborne, 4th Duke of Leeds (1713–1789), English Justice in Eyre and Cofferer of the Household Thomas Osborne (publisher) (1704?–1767), English publisher and bookseller
Ireland Sir Thomas Osborne, 5th Baronet (1639–1715), Irish baronet and landowner Sir Thomas Osborne, 9th Baronet (1757–1821), Irish baronet and politician
United States Listed chronologically by year of birth Thomas Burr Osborne (politician) (1798–1869), U.S. representative from Connecticut Thomas A. Osborne (1800–1877), American lawyer and politician in New York Thomas O. Osborn (1832–1904), American lawyer, soldier, and diplomat Thomas W. Osborn (1833–1898), U.S. senator from Florida Thomas A. Osborn (1836–1898), American lawyer, politician, and diplomat Thomas Mott Osborne (1859–1926), American prison reformer Thomas Burr Osborne (chemist) (1859–1929), American chemist, co-discoverer of Vitamin A T. L. Osborn (Tommy Lee Osborn), American Pentecostal televangelist, singer, author and teacher Tom Osborne (born 1937), American college football head coach (Nebraska), and member of Congress Tom Osborne (American football, born 1960), American football coach (Oregon) Tom Osborne (engineer), American engineer who created the Green Machine which led to the Hewlett-Packard 9100A
Elsewhere Thomas Osborne (Australian journalist) (c. 1806–1853), Australian journalist and politician in the Victorian Legislative Council Tom Osborne (Canadian politician) (born 1964), Canadian politician in Newfoundland and Labrador Tom Osborne (rugby union) (born 1998), Australian rugby player
See also Thomas Osborne Davis (Canadian politician) (1856–1917) Thomas Osborne Davis (Irish politician) (1814–1845)