Santa Cruz, or Santacruz, or de la Santacruz, are surnames of Spanish and Portuguese origin, evolving from Latin to medieval Castilian, Sancta Crux → Santa Cruz, referring to the holy cross, a symbol of Christianity. Family records are documented in Castile, Aragon, and Navarre during the XV century.

Notable people with this name Arts and entertainment Abel Santa Cruz (1915–1995), major Argentine screenwriter Daniel Santacruz (born 1976), American musician, singer and record producer Francesc Santacruz i Artigas (fl. 1665–1721), Catalan sculptor Kendra Santacruz (born 1989), Mexican television actress Pedro Ferriz Santacruz (1921–2013), veteran radio and television presenter in Mexico

Sports Danilo Santacruz (born 1995), Paraguayan footballer Estéban Santa Cruz (1885–?), Cuban baseball player Hugo Santacruz (born 1989), Paraguayan footballer Javier Flores Santacruz (born 1986), Spanish footballer José Armando Santa Cruz (born 1980), a Mexican boxer Rafael Carlos Santacruz (born 1983), Spanish footballer Roque Santa Cruz (born 1981), Paraguayan footballer Victor Santa Cruz (born 1972), American college football coach

Other people Álvaro de Bazán, 1st Marquis of Santa Cruz (1526–1588), Spanish admiral Andrés de Santa Cruz (1792–1865), president of Peru and Bolivia Hernán Santa Cruz (1906–1999), Chilean lawyer and diplomat José Santacruz Londoño (1943–1996), Colombian drug lord Lorenzo Carbonell Santacruz (1883–1968), mayor of Alicante, 1931–1936 Manuel Santa Cruz Loidi (1842–1926), Spanish Carlist guerilla leader and missionary Manuel de Santa Cruz (1922–2019), pen-name of Alberto Ruiz de Galarreta Mocoroa, Spanish historian Roque González de Santa Cruz (1576–1628), Paraguayan saint

See also Cruz De la Cruz Santa Cruz (disambiguation)