12B is a 2001 Indian Tamil-language film by Jeeva.

12B may also refer to:

New York State Route 12B, a state highway in the central part of New York Missouri Route 12B Nebraska Spur 12B WASP-12b, an extrasolar planet HAT-P-12b, an extrasolar planet Boron-12 (12B), an isotope of boron 12B, a short-lived Mazda Wankel engine 12B United States MOS enlisted (military occupational specialty) for "Combat Engineer" 12b, an alternative name for the Ontario Academic Credit program

See also B12 (disambiguation)