2010 Samarkand Challenger – Singles

Dustin Brown was the defending champion, but he chose to compete in Istanbul challenger instead. Andrej Martin won the title, after won 6–4, 7–5 against his compatriot Marek Semjan in the final.

Seeds

Blaž Kavčič (quarterfinals) Óscar Hernández (first round) Andrey Kuznetsov (second round) Guillaume Rufin (first round) Evgeny Kirillov (second round) Andrej Martin (champion) Marek Semjan (final) Andis Juška (semifinals, retired due to stomach ache)