Phi Chi, one of the oldest medical fraternities in the world, was established on March 5, 1905. It was formed by the merger of two professional medical fraternities with the same name. Phi Chi Society (Phi Chi East) was founded on March 31, 1889, at the University of Vermont. Phi Chi Medical Fraternity (Phi Chi South) was founded on October 26, 1894, at the Louisville Medical College. These two organizations did not know they shared a similar name when they were founded.

On March 5, 1905, in Burlington, Vermont, Phi Chi Society and Phi Chi Medical Fraternity, Inc., were consolidated taking the name Phi Chi Medical Fraternity, Inc. Phi Chi East had five active chapters at the time of the merger. Phi Chi South had eighteen active chapters at the time of the merger. Phi Chi also merged with the Pi Mu Honor Society on October 7, 1922, acquiring a new chapter and absorbing six chapters.

Chapters When the Phi Chi Society and Phi Chi Medical Fraternity combined in 1905, it was decided that when the names of any two chapters conflicted, the chapter with precedence would retain its single-letter name and the chapter with the later chapter date would duplicate its name. The result was retaining the Alpha chapter (1889) at the University of Vermont as named, and renaming the former Alpha chapter of Louisville (1894) as Alpha Alpha chapter, and so forth.

Following is a list of chapters. Active chapters are indicated in bold. Inactive chapters are in italics.

Chapter Charter date and range InstitutionLocationStatusAlpha – 1967University of Vermont College of MedicineBurlington, VermontInactiveAlpha Alpha – 1908Louisville Medical CollegeLouisville, KentuckyInactiveBeta Beta (see Pi Sigma) –1913Baltimore Medical College, University of MarylandBaltimore, MarylandConsolidatedBeta First (see Gamma) – 1909Kentucky School of MedicineLouisville, KentuckyConsolidated, ReissuedGamma First (see Gamma Epsilon) – 1907University of LouisvilleLouisville, KentuckyConsolidated, ReissuedDelta First – 1908Hospital College of MedicineLouisville, KentuckyReissuedEpsilon First (see Gamma Epsilon) – 1907Kentucky University Medical DepartmentLexington, KentuckyConsolidated, ReissuedTheta – 1913University College of MedicineRichmond, VirginiaConsolidatedGamma Gamma – June 30, 1921Bowdoin Medical College (Medical College of Maine) Brunswick, MaineInactiveDelta Delta (see Beta Delta) – 1915University College of Physicians and SurgeonsBaltimore, MarylandConsolidatedEta Second – 1913Medical College of VirginiaRichmond, VirginiaConsolidatedKappa – 1971Georgetown University School of MedicineWashington, D.C.InactiveOmicronTulane University of Louisiana School of MedicineNew Orleans, LouisianaActiveTheta Theta (see Pi Sigma) – 1907Maryland Medical CollegeBaltimore, MarylandConsolidatedMu – 1975Purdue University School of MedicineIndianapolis, IndianaConsolidated Nu (see Iota) – June 1, 1913Birmingham Medical CollegeTuscaloosa, AlabamaConsolidatedZetaUniversity of Texas Medical BranchGalveston, TexasActiveChiSidney Kimmel Medical College Philadelphia, PennsylvaniaActiveIota – 19xx ?; – 1963University of Alabama School of MedicineBirmingham, AlabamaInactive Phi – 1978George Washington University Medical SchoolWashington, D.C.InactiveLambda – June 1, 1911 University of Pittsburgh School of MedicinePittsburgh, PennsylvaniaInactivePi – 1976Vanderbilt University School of MedicineNashville, TennesseeInactive Rho – 1944Rush Medical CollegeChicago, IllinoisInactiveSigma (see Upsilon) – 1973Emory University School of MedicineAtlanta, GeorgiaInactive Sigma Theta – 1965University of North Carolina School of MedicineChapel Hill, North CarolinaInactive Tau (see Sigma Kappa) – June 1, 1924Medical College of the State of South CarolinaCharleston, South CarolinaReestablished PsiUniversity of Michigan Medical SchoolAnn Arbor, MichiganActive Upsilon (see Sigma) – 1917Atlanta School of MedicineAtlanta, GeorgiaConsolidated Alpha Theta – 1941Western Reserve UniversityCleveland, OhioInactive Sigma Mu Chi – June 1, 1910Chattanooga Medical CollegeChattanooga, TennesseeInactive Gamma Epsilon (see Gamma and Epsilon) – 1909University of KentuckyLexington, Kentucky Inactive Pi Sigma (see Beta Delta) – 1915University of MarylandCollege Park, MarylandConsolidated Xi First – December 10, 1919Texas Christian UniversityFort Worth, TexasMovedThe ''Xi chapters charter was transferred from Texas Christian to Baylor.|name=Xi Chapter}} |- | Phi Sigma | – 1973; 1985–1989 |Stritch School of Medicine |Chicago, Illinois |Inactive|| |- | Chi Theta (see Upsilon Pi) | – October 1, 1917 |Medico-Chirurgical College of Philadelphia |Philadelphia, Pennsylvania |Consolidated

| Alpha Delta |1908–1909 |Louisville and Hospital College |Louisville, Kentucky |Inactive

| Kappa Psi (see Phi Rho) | – 1911 |College of Physicians & Surgeons |St. Louis, Missouri |Consolidated

| Upsilon Pi | – 1969 |University of Pennsylvania School of Medicine |Philadelphia, Pennsylvania |Inactive|| |- | Pi Delta Phi First | – Fall 1911 |University of California, Los Angeles |Los Angeles, California |Moved|| |- | Phi Beta (see Upsilon Iota) | – 1916 |University of Illinois |Chicago, Illinois |Consolidated|| |- | Psi Rho Sigma (see Kappa Rho) | – 1913 |Northwestern University School of Medicine |Chicago, Illinois |Reestablished

| Iota Pi (see Delta Phi) | – June 1, 1920 |University of Southern California School of Medicine |Los Angeles, California | Reestablished

| Kappa Delta | – 1967 |Johns Hopkins University School of Medicine |Baltimore, Maryland |Inactive

| Alpha Mu (see Mu) | – 1917 |Indiana University School of Medicine |Bloomington, Indiana |Consolidated

| Theta Upsilon | – 1971 |Temple University School of Medicine |Philadelphia, Pennsylvania |Inactive|| |- | Phi Rho (see Kappa Psi and Kappa Upsilon) | –2014 |Saint Louis University School of Medicine |Saint Louis, Missouri |Inactive

|Pi Delta Phi Second | – 1967 |University of California, Berkeley |Berkeley, California |Inactive

| Theta Eta |–1977 |Medical College of Virginia School of Medicine |Richmond, Virginia |Inactive

| Sigma Upsilon | – 1937 |Stanford University School of Medicine |San Francisco, California |Inactive|| |- | Gamma Second | –1962 |Ohio State University College of Medicine |Columbus, Ohio |Inactive|| |- | Delta Second | – 1957 |Tufts University School of Medicine |Boston, Massachusetts |Inactive|| |- | Beta Second | – 19xx ?; –1931 |University of Oregon Medical School |Portland, Oregon |Inactive|| |- | Epsilon Second | – 19xx ?; – 1942 |Wayne State University School of Medicine |Detroit, Michigan |Inactive|| |- | Alpha Beta| |University of Tennessee Health Science Center |Memphis, Tennessee |Active

| Lambda Rho | – 19xx ?; – 1968 |University of Arkansas College of Medicine |Little Rock, Arkansas |Inactive|| |- | Kappa Upsilon (see Phi Rho) | – 1954 |University of Kansas Medical Center |Lawrence, Kansas |Consolidated

| Beta Delta |1915 – 1950 |University of Maryland, Baltimore School of Medicine |Baltimore, Maryland |Inactive|| |- | Chi Upsilon| |Creighton University School of Medicine |Omaha, Nebraska |Active

| Upsilon Nu| |University of Nebraska Medical School |Omaha, Nebraska |Active|| |- | Upsilon Zeta | – 1971 |University of Cincinnati College of Medicine |Cincinnati, Ohio |Inactive|| |- | Upsilon Iota (see Phi Beta) |– 1952 |University of Illinois School of Medicine |Chicago, Illinois |Inactive

|Xi Second | – 192x ? |Baylor College of Medicine |Dallas, Texas |Reissused, Reestablished

| Kappa Rho (see Psi Rho Sigma) | – 1971 |Northwestern University Medical School |Chicago, Illinois |Inactive

| Delta Pi | – 1945 |University of Utah School of Medicine |Salt Lake City, Utah |Inactive

| Kappa Chi| – 1974; 1981 |University of Minnesota Medical School |Minneapolis, Minnesota |Active

| Upsilon Sigma | – 1958 |Columbia University College of Physicians and Surgeons |New York, New York |Inactive

|Epsilon Chi | – 19xx ? |Marquette University |Milwaukee, Wisconsin |Inactive

|Rho Delta | – 1956 |Cornell University Medical School |New York, New York |Inactive

| Beta Chi | – 1937 |University of Colorado School of Medicine |Denver, Colorado |Inactive

| Tau Beta | – 1974 |University of Wisconsin Medical School |Madison, Wisconsin |Inactive

|Xi Third |– 1971 |University of Texas Southwestern Medical School |Dallas, Texas |Inactive

| Sigma Delta | – 1942 |University of South Dakota School of Medicine |Vermillion, South Dakota |Inactive

| Eta Upsilon | – 1935 |Harvard Medical School |Boston, Massachusetts |Inactive|| |- | Beta Upsilon | – 1958 |Boston University School of Medicine |Boston, Massachusetts |Inactive

| Epsilon Delta | – 1939 |Washington University School of Medicine |St. Louis, Missouri |Inactive

| Beta Mu | – 1944 |McGill University Faculty of Medicine |Montreal, Canada |Inactive

| Pi Mu | – 1972 |University of Virginia School of Medicine |Charlottesville, Virginia |Inactive

| Omicron Kappa | – 1960 |University of Oklahoma College of Medicine |Oklahoma City, Oklahoma |Inactive

| Gamma Sigma | – 1943 |Yale School of Medicine |New Haven, Connecticut |Inactive

| Tau Omicron | – 1969 |University of Toronto Medical School |Toronto, Ontario, Canada |Inactive

| Mu Gamma | – 1951 |University of Iowa College of Medicine |Iowa City, Iowa |Inactive

| Theta Pi |1926–1976 |University of Mississippi School of Medicine |Jackson, Mississippi |Inactive

| Sigma Kappa (see Tau) | |Medical University of South Carolina |Charleston, South Carolina |Active

| Nu Sigma |1928–2009 |Dalhousie University Faculty of Medicine |Halifax, Nova Scotia, Canada |Inactive

| Delta Phi (see Iota Pi) |1929–1970 |University of Southern California School of Medicine |Los Angeles, California |Inactive

| Theta Beta Pi |1929–1944 |Syracuse University College of Medicine |Syracuse, New York |Inactive

| Delta Kappa Upsilon |1929–1940 |University of Kansas Medical Center |Kansas City, Kansas |Inactive

| Delta Upsilon |1930–1978 |Duke University School of Medicine |Durham, North Carolina |Inactive

| Alpha Phi Sigma |1931–1978 |Medical College of Georgia |Augusta, Georgia |Inactive

| Alpha Sigma |1932–1975 |Louisiana State University Medical Center |New Orleans, Louisiana |Inactive

| Gamma Chi |1933–1966 |West Virginia University School of Medicine |Morgantown, West Virginia |Inactive

| Omega Upsilon Phi |1934–1973 |University at Buffalo School of Medicine and Biomedical Sciences |Buffalo, New York |Inactive

| Tau Kappa |1935–1969 |Wake Forest School of Medicine |Winston-Salem, North Carolina |Inactive

| Alpha Mu |1938–1960 |The State University of New York Health Science Center at Brooklyn |Brooklyn, New York |Inactive

| Xi Chi (see Xi Second) |1943–1975 |Baylor College of Medicine |Houston, Texas |Inactive

| Phi Alpha |1948–1978 |New York Medical College |Valhalla, New York |Inactive

| Phi Alpha Gamma |1948–1964 |Hahnemann Medical College of Philadelphia |Philadelphia, Pennsylvania |Inactive

| Epsilon Kappa| |University of Washington School of Medicine |Seattle, Washington |Active

| Epsilon Beta |1952–1967 |University of California Medical School |Los Angeles, California |Inactive

| Beta Alpha |1953–1974 |University of Miami School of Medicine |Miami, Florida |Inactive

| Mu Sigma |1955–1967 |University of Missouri School of Medicine |Columbia, Missouri |Inactive

| Omega |1960–1968 |University of Mexico |Mexico City, Mexico |Inactive

| Upsilon Beta Second |1962–1972 |University of Puerto Rico School of Medicine |San Juan, Puerto Rico |Inactive

| Phi Sigma Gamma |1963–1967 |University of California, Los Angeles School of Medicine |Los Angeles, California |Inactive

| Upsilon Tau |1970–1973 |University of Texas Health Science Center at San Antonio |San Antonio, Texas |Inactive

| Upsilon Alpha |1981–1985 |University of Arizona College of Medicine |Tucson, Arizona |Inactive

| Sigma Chi Mu| |American University of the Caribbean School of Medicine |St. Maarten, Netherlands Antilles |Active