Růžena is a Czech feminine given name, meaning Rose. Notable people with the given name include:
Ruzena Bajcsy (born 1933), American engineer and computer scientist Ruzena Herlinger (1890–1978), Czech-Canadian soprano, voice teacher Růžena Jesenská (1863–1940), Czech teacher, poet and writer Růžena Košťálová (1924–2024), Czechoslovak sprint canoeist Růžena Maturová (1869–1938), Czech operatic soprano Růžena Novotná (born 1941), Czechoslovak slalom canoeist Růžena Svobodová (1868–1920), Czech writer Růžena Nasková (1884–1960), Czech actress Růžena Vacková (1901–1982), Czech historian and theoretician Růžena Šlemrová (1886–1962), Czech actress
See also 1856 Růžena, an asteroid Růžená, a municipality in the Vysočina Region, Czech Republic