Big Snake may refer to:
People Robin Big Snake (born 1984), Canadian former professional hockey player Omoxesisixany, a chief of the Blackfoot Native American tribe Big Snake (Ponca chief), a chief of the Ponca Native American tribe, and brother of the chief Standing Bear
Other: Snake Creek (Susquehanna River), Pennsylvania, sometimes called Big Snake Creek
See also Grootslang (Dutch for "big snake"), a legendary cryptid alleged to live in South Africa