Luis Núñez or Luis Nuñez may refer to:
Luis Núñez (athlete) (born 1964), Dominican Republic athlete Luis Núñez (footballer, born May 1980), Paraguayan footballer for Sportivo Luqueño Luis Núñez (footballer, born 1983), Colombian footballer for Boyacá Chicó Luis Núñez Astrain (1931–2009), Spanish-Basque linguist and sociologist, editor of the newspaper Egin Luis Patricio Núñez (born January 1980), former Chilean footballer