The Santosham Best Debut Actress Award is given by the Santosham Film magazine as part of its annual Santosham Film Awards for Telugu films.

The award was first given to Kamalinee Mukherjee in 2003. Here is a list of the award winners and the films for which they won.

Year Actress Film 2023 Vaishnavi Chaitanya Baby 2019 Shivathmika Rajashekar Dorasaani 2015 Hebah Patel Kumari 21F 2014 Pooja Hegde Oka Laila Kosam 2009 Karthika Nair Josh 2008 Sneha Ullal Ullasamga Utsahamga 2007 Hansika Motwani Desamuduru 2003 Kamalinee Mukherjee Anand

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