Francesco I may refer to:
Persons Pope Francis (1936–2025, reigned 2013–2025), also known in Latin as Franciscus Francesco I Ordelaffi (c. 1300 – 1332) Francesco I of Lesbos (died 1384) Francesco I Crispo (died 1397) Francesco I Gonzaga (1366–1407) Francesco I Acciaioli (fl. 1451–1453) Francesco I Sforza (1401–1466) Francesco I d'Este, Duke of Modena (1610–1658) Francesco I of the Two Sicilies (1777–1830)
Fictional characters Papa Francesco I, the fictional pope / character in the 1979 Walter Murphy novel Vicar of Christ
See also Francis I (disambiguation)