The 2006 Soul Train Music Awards were held on March 18, 2006 at the Pasadena Conference Center in Pasadena, California and was hosted by Vivica Fox and Tyrese. The show marked the 20th Anniversary of the Soul Train Music Awards.

Special awards Quincy Jones Award for Outstanding Career Achievements – Female Destiny's Child

Quincy Jones Award for Outstanding Career Achievements – Male Jamie Foxx

Stevie Wonder Award for Outstanding Achievement in Songwriting R. Kelly

Sammy Davis, Jr. Award for "Entertainer of the Year" John Legend

Winners and nominees Winners are in bold text.

Best R&B/Soul Album – Male John Legend – Get Lifted Anthony Hamilton – Soulife R. Kelly – TP.3 Reloaded Marques Houston – Naked

Best R&B/Soul Album – Female Mariah Carey – The Emancipation of Mimi Keyshia Cole – The Way It Is Faith Evans – The First Lady Fantasia – Free Yourself

Best R&B/Soul Album – Group, Band or Duo The Black Eyed Peas – Monkey Business 112 – Pleasure & Pain Earth, Wind & Fire – Illumination Mint Condition – Livin' the Luxury Brown

Best R&B/Soul Single – Male John Legend – "Ordinary People" Chris Brown – "Run It!" Bobby Valentino – "Slow Down" Charlie Wilson – "Charlie, Last Name Wilson"

Best R&B/Soul Single – Female Mariah Carey – "We Belong Together" Keyshia Cole – "I Should Have Cheated" Alicia Keys – "Unbreakable" Gwen Stefani – "Hollaback Girl"

Best R&B/Soul Single – Group, Band or Duo Destiny's Child – "Cater 2 U" Floetry – "Supastar" Pussycat Dolls – "Don't Cha" Nina Sky – "Turnin' Me On"

The Michael Jackson Award for Best R&B/Soul or Rap Music Video Kanye West – "Gold Digger" Common – "Testify" Missy Elliott – "Lose Control" Lil Wayne – "Fireman"

The Coca-Cola Classic Award for Best R&B/Soul or Rap New Artist Chris Brown Leela James Lyfe Jennings Bobby Valentino

The Sprite Award for Best R&B/Soul or Rap Dance Cut Missy Elliott – "Lose Control" The Black Eyed Peas – "My Humps" Gwen Stefani – "Hollaback Girl" Kanye West – "Gold Digger"

Best Gospel Album Donnie McClurkin – Psalms, Hymns & Spiritual Songs Kurt Carr Project – One Church Kirk Franklin – Hero CeCe Winans – Purified

Performers The Black Eyed Peas John Legend Chris Brown Pussycat Dolls and Avant Keyshia Cole Charlie Wilson Flipsyde