The John W. Huffman research group at Clemson University synthesized over 450 cannabinoids. Some of those are:
+ Cannabinoids and their Ki valuesNameClassKi / nM at CB1Ki / nM at CB2SelectivityStructureJWH-004 Naphthoylindole 48 ± 13 4 ± 1.5 CB2 (12x) JWH-007 Naphthoylindole 9.5 ± 4.5 2.9 ± 2.6 CB2 (3.3x) JWH-009 Naphthoylindole >10000 141 ± 14 CB2 (>70x) JWH-011 Naphthoylindole JWH-015 Naphthoylindole 164 ± 22 13.8 ± 4.6 CB2 (12x) JWH-016 Naphthoylindole 22 ± 1.5 4.3 ± 1.6 CB2 (5.1x) JWH-018 Naphthoylindole 9 ± 5 2.9 ± 2.6 CB2 (3.1x) JWH-019 Naphthoylindole 9.8 ± 2 5.55 ± 2 CB2 (1.77x) JWH-020 Naphthoylindole 128 ± 17 205 ± 20 CB1 (1.6x) JWH-030 Naphthoylpyrrole 87 ± 3 320 ± 127 CB1 (3.7x) JWH-031 Naphthoylpyrrole 399 ± 109 JWH-032 Naphthoylpyrrole >10000 >10000 — JWH-033 Naphthoylpyrrole 666 ± 77 JWH-036 Naphthoylpyrrole 309 ± 11 JWH-042 Naphthoylindole >10000 5050 ± 192 CB2 JWH-043 Naphthoylindole 1180 ± 44 964 ± 242 CB2 (1.2x) JWH-044 Naphthoylpyrrole >10000 >10000 — JWH-045 Naphthoylpyrrole >10000 >10000 — JWH-046 Naphthoylindole 343 ± 38 16.3 ± 4.9 CB2 (21x) JWH-047 Naphthoylindole 59 ± 3 3.47 ± 1.80 CB2 (17x) JWH-048 Naphthoylindole 10.7 ± 1.0 0.49 ± 0.13 CB2 (22x) JWH-049 Naphthoylindole 55.1 ± 17.0 32.3 ± 2.4 CB2 (1.7x) JWH-050 Naphthoylindole 342 ± 6 526 ± 133 CB1 (1.5x) JWH-051 Dibenzopyran 1.20 0.03 CB2 (40x) JWH-056 Dibenzopyran >10000 32 ± 9 CB2 JWH-057 Dibenzopyran 23 ± 7 2.9 ± 1.6 CB2 (8x) JWH-065 Dibenzopyran 399 ± 76 10 ± 2 CB2 (40x) JWH-070 Naphthoylindole >10000 >10000 JWH-071 Naphthoylindole 1340 ± 123 2940 ± 852 CB1 (2.2x) JWH-072 Naphthoylindole 1050 ± 5.5 170 ± 54 CB2 (6x) JWH-073 Naphthoylindole 8.9 ± 1.8 27 ± 12 CB1 (3x) JWH-076 Naphthoylindole 214 ± 11 106 ± 46 CB2 (2x) JWH-077 Naphthoylindole >10000 >10000 JWH-078 Naphthoylindole 817 ± 60 633 ± 116 CB2 (1.3x) JWH-079 Naphthoylindole 63.0 ± 3.0 32.0 ± 6.0 CB2 (2x) JWH-080 Naphthoylindole 8.9 ± 1.8 2.21 ± 1.30 CB2 (4x) JWH-081 Naphthoylindole 1.2 ± 0.03 12.4 ± 2.2 CB1 (10x) JWH-082 Naphthoylindole 5.3 ± 0.8 6.40 ± 0.94 CB1 (1.2x) JWH-083 Naphthoylindole 106 ± 12 102 ± 50 — JWH-091 (Δ8-THCP) Dibenzopyran 22.0 ± 3.9 JWH-093 Naphthoylindole 40.7 ± 2.8 59.1 ± 10.5 CB1 (1.45x) JWH-094 Naphthoylindole 476 ± 67 97.3 ± 2.7 CB2 (4.9x) JWH-095 Naphthoylindole 140 ± 4.3 312 ± 83 CB1 (2.2x) JWH-096 Naphthoylindole 33.7 ± 2.9 13.3 ± 5.6 CB2 (2.5x) JWH-097 Naphthoylindole 455 ± 28 121 ± 15 CB2 (3.8x) JWH-098 Naphthoylindole 4.5 ± 0.1 1.9 ± 0.3 CB2 (2.4x) JWH-099 Naphthoylindole 35.3 ± 9.0 17.8 ± 2.9 CB2 (2x) JWH-100 Naphthoylindole 381 ± 102 155 ± 74 CB2 (2.5x) JWH-102 Dibenzopyran 7.9 ± 0.9 5.2 ± 2.0 CB2 (1.5x) JWH-103 Dibenzopyran 28 ± 3 23 ± 7 CB2 (1.2x) JWH-116 Naphthoylindole 52 ± 5 JWH-120 Naphthoylindole 1054 ± 31 6.1 ± 0.7 CB2 (173x) JWH-122 Naphthoylindole 0.69 ± 0.05 1.2 ± 1.2 — JWH-124 (Δ8-Parahexyl) Dibenzopyran 41.0 ± 3.8 JWH-130 (Δ8-THCB) Dibenzopyran 65.0 ± 13 JWH-133 Dibenzopyran 677 ± 132 3.4 ± 1.0 CB2 (200x) JWH-138 Dibenzopyran 8.5 ± 1.4 JWH-139 Dibenzopyran 2290 ± 505 14 ± 10 CB2 (164x) JWH-142 Dibenzopyran 529 ± 49 35 ± 14 CB2 (15x) JWH-143 Dibenzopyran 924 ± 104 65 ± 8 CB2 (14x) JWH-145 Naphthoylpyrrole 14 ± 2 6.4 ± 0.4 CB2 (2.2x) JWH-146 Naphthoylpyrrole 21 ± 2 62 ± 5 CB2 (3.0x) JWH-147 Naphthoylpyrrole 11 ± 1 7.1 ± 0.2 CB2 (1.5x) JWH-148 Naphthoylindole 123 ± 8 14.0 ± 1.0 CB2 (8x) JWH-149 Naphthoylindole 5.0 ± 2.1 0.73 ± 0.03 CB2 (6.8x) JWH-150 Naphthoylpyrrole 60 ± 1 15 ± 2 CB2 (4x) JWH-151 Naphthoylindole >10000 30 ± 1.1 CB2 (>333x) JWH-153 Naphthoylindole 250 ± 24 11 ± 0.5 CB2 (23x) JWH-156 Naphthoylpyrrole 404 ± 18 104 ± 18 CB2 (4x) JWH-159 Naphthoylindole 45 ± 1 10.4 ± 1.4 CB2 (4.3x) JWH-160 Naphthoylindole 1568 ± 201 441 ± 110 CB2 (3.6x) JWH-161 Dibenzopyran hybrid 19.0 JWH-163 Naphthoylindole 2358 ± 215 138 ± 12 CB2 (17x) JWH-164 Naphthoylindole 6.6 ± 0.7 6.9 ± 0.2 — JWH-165 Naphthoylindole 204 ± 26 71 ± 8 CB2 (2.9x) JWH-166 Naphthoylindole 44 ± 10 1.9 ± 0.08 CB2 (23x) JWH-167 Phenylacetylindole 90 ± 17 159 ± 14 CB1 (1.77x) JWH-171 Hydrocarbon 51 JWH-175 Naphthylmethylindole 22 ± 2 JWH-176 Hydrocarbon 26 ± 4 JWH-180 Naphthoylindole 26 ± 2 9.6 ± 2.0 CB2 (2.7x) JWH-181 Naphthoylindole 1.3 ± 0.1 0.62 ± 0.04 CB2 (2.1x) JWH-182 Naphthoylindole 0.65 ± 0.03 1.1 ± 0.1 CB1 (1.7x) JWH-184 Naphthylmethylindole 23 ± 6 JWH-185 Naphthylmethylindole 17 ± 3 JWH-186 Dibenzopyran 187 ± 23 5.6 ± 1.7 CB2 (33x) JWH-187 Dibenzopyran 84 ± 16 3.4 ± 0.5 CB2 (25x) JWH-188 Dibenzopyran 270 ± 58 18 ± 2 CB2 (15x) JWH-189 Naphthoylindole 52 ± 2 12 ± 0.8 CB2 (4.3x) JWH-190 Dibenzopyran 8.8 ± 1.4 1.6 ± 0.03 CB2 (5.5x) JWH-191 Dibenzopyran 1.8 ± 0.3 0.52 ± 0.03 CB2 (3.5x) JWH-192 Naphthylmethylindole 41 ± 13 JWH-193 Naphthoylindole 6 ± 1 JWH-194 Naphthylmethylindole 127 ± 19 JWH-195 Naphthylmethylindole 113 ± 28 JWH-196 Naphthylmethylindole 151 ± 18 JWH-197 Naphthylmethylindole 323 ± 98 JWH-198 Naphthoylindole 10 ± 2 JWH-199 Naphthylmethylindole 20 ± 2 JWH-200 Naphthoylindole 42 ± 5 JWH-201 Phenylacetylindole 1064 ± 21 444 ± 14 CB2 (2.4x) JWH-202 Phenylacetylindole 1678 ± 63 645 ± 6 CB2 (2.6x) JWH-203 Phenylacetylindole 8.0 ± 0.9 7.0 ± 1.3 — JWH-204 Phenylacetylindole 13 ± 1 25 ± 1 CB1 (1.9x) JWH-205 Phenylacetylindole 124 ± 23 180 ± 9 CB1 (1.45x) JWH-206 Phenylacetylindole 389 ± 25 498 ± 37 CB1 (1.28x) JWH-207 Phenylacetylindole 1598 ± 134 3723 ± 10 CB1 (2.33x) JWH-208 Phenylacetylindole 179 ± 7 570 ± 127 CB1 (3.18x) JWH-209 Phenylacetylindole 746 ± 49 1353 ± 270 CB1 (1.81x) JWH-210 Naphthoylindole 0.46 ± 0.03 0.69 ± 0.01 CB1 (1.5x) JWH-211 Naphthoylindole 70 ± 0.8 12 ± 0.8 CB2 (5.8x) JWH-212 Naphthoylindole 33 ± 0.9 10 ± 1.2 CB2 (3.3x) JWH-213 Naphthoylindole 1.5 ± 0.2 0.42 ± 0.05 CB2 (3.6x) JWH-215 Dibenzopyran 1008 ± 117 85 ± 21 CB2 (12x) JWH-216 Dibenzopyran 1856 ± 148 333 ± 104 CB2 (5.6x) JWH-217 Dibenzopyran >10000 1404 ± 66 CB2 (>7x) JWH-220 Hydrocarbon 19 JWH-224 Dibenzopyran 347 ± 34 28 ± 1 CB2 (12.3x) JWH-225 Dibenzopyran >10000 325 ± 70 CB2 (>31x) JWH-226 Dibenzopyran 4001 ± 282 43 ± 3 CB2 (93x) JWH-227 Dibenzopyran 40 ± 6 4.4 ± 0.3 CB2 (9x) JWH-229 Dibenzopyran 3134 ± 110 18 ± 2 CB2 (174x) JWH-230 Dibenzopyran 15 ± 3 1.4 ± 0.12 CB2 (10.7x) JWH-233 Dibenzopyran 14 ± 3 1.0 ± 0.3 CB2 (14x) JWH-234 Naphthoylindole 8.4 ± 1.8 3.8 ± 0.6 CB2 (2.2x) JWH-235 Naphthoylindole 338 ± 34 123 ± 34 CB2 (2.7x) JWH-236 Naphthoylindole 1351 ± 204 240 ± 63 CB2 (5.6x) JWH-237 Phenylacetylindole 38 ± 10 106 ± 2 CB1 (2.8x) JWH-239 Naphthoylindole 342 ± 20 52 ± 6 CB2 (6.6x) JWH-240 Naphthoylindole 14 ± 1 7.2 ± 1.3 CB2 (1.9x) JWH-241 Naphthoylindole 147 ± 20 49 ± 7 CB2 (3.0x) JWH-242 Naphthoylindole 42 ± 9 6.5 ± 0.3 CB2 (6.5x) JWH-243 Naphthoylpyrrole 285 ± 40 41 ± 3 CB2 (6.95x) JWH-244 Naphthoylpyrrole 130 ± 6 18 ± 1 CB2 (7.22x) JWH-245 Naphthoylpyrrole 276 ± 4 25 ± 2 CB2 (11x) JWH-246 Naphthoylpyrrole 70 ± 4 16 ± 1 CB2 (4.38x) JWH-247 Dibenzopyran 427 ± 31 99 ± 4 CB2 (4.3x) JWH-248 Phenylacetylindole 1028 ± 39 657 ± 19 CB2 (1.56x) JWH-249 Phenylacetylindole 8.4 ± 1.8 20 ± 2 CB1 (2.38x) JWH-250 Phenylacetylindole 11 ± 2 33 ± 2 CB1 (3x) JWH-251 Phenylacetylindole 29 ± 3 146 ± 36 CB2 (5x) JWH-252 Phenylacetylindole 23 ± 3 19 ± 1 CB2 (1.2x) JWH-253 Phenylacetylindole 62 ± 10 84 ± 12 CB1 (1.35x) JWH-254 Dibenzopyran 4724 ± 509 319 ± 16 CB2 (14.8x) JWH-256 Dibenzopyran 4300 ± 888 97 ± 18 CB2 (44x) JWH-258 Naphthoylindole 4.6 ± 0.6 10.5 ± 1.3 CB1 (2.3x) JWH-259 Naphthoylindole 220 ± 29 74 ± 7 CB2 (3.0x) JWH-260 Naphthoylindole 29 ± 0.4 25 ± 1.9 CB2 (1.2x) JWH-261 Naphthoylindole 767 ± 105 221 ± 14 CB2 (3.5x) JWH-262 Naphthoylindole 28 ± 3 5.6 ± 0.7 CB2 (5.0x) JWH-265 Naphthoylindole 3788 ± 323 80 ± 13 CB2 (47x) JWH-266 Naphthoylindole >10000 455 ± 55 CB2 (>22x) JWH-267 Naphthoylindole 381 ± 16 7.2 ± 0.14 CB2 (53x) JWH-268 Naphthoylindole 1379 ± 193 40 ± 0.6 CB2 (34x) JWH-277 Dibenzopyran 3905 ± 91 589 ± 65 CB2 (6.6x) JWH-278 Dibenzopyran 906 ± 80 69 ± 6 CB2 (13x) JWH-292 Naphthoylpyrrole 29 ± 1 20 ± 1 CB2 (1.45x) JWH-293 Naphthoylpyrrole 100 ± 5 41 ± 4 CB2 (2.44x) JWH-298 Dibenzopyran 812 ± 67 198 ± 23 CB2 (4.1x) JWH-299 Dibenzopyran 415 ± 50 30 ± 2 CB2 (13.8x) JWH-300 Dibenzopyran 118 ± 16 5.3 ± 0.1 CB2 (22x) JWH-301 Dibenzopyran 295 ± 64 48 ± 4 CB2 (6.1x) JWH-302 Phenylacetylindole 17 ± 2 89 ± 15 CB1 (5.26x) JWH-303 Phenylacetylindole 117 ± 10 138 ± 12 CB1 (1.18x) JWH-304 Phenylacetylindole 3363 ± 332 2679 ± 688 CB2 (1.26x) JWH-305 Phenylacetylindole 15 ± 1.8 29 ± 5 CB1 (1.93x) JWH-306 Phenylacetylindole 25 ± 1 82 ± 11 CB1 (3.28x) JWH-307 Naphthoylpyrrole 7.7 ± 1.8 3.3 ± 0.2 CB2 (2.33x) JWH-308 Naphthoylpyrrole 41 ± 1 33 ± 2 CB2 (1.24x) JWH-309 Naphthoylpyrrole 41 ± 3 49 ± 7 CB1 (1.20x) JWH-310 Dibenzopyran 1059 ± 51 36 ± 3 CB2 (29x) JWH-311 Phenylacetylindole 23 ± 2 39 ± 3 CB1 (1.70x) JWH-312 Phenylacetylindole 72 ± 7 91 ± 20 CB1 (1.26x) JWH-313 Phenylacetylindole 422 ± 19 365 ± 92 CB2 (1.16x) JWH-314 Phenylacetylindole 39 ± 2 76 ± 4 CB1 (1.95x) JWH-315 Phenylacetylindole 430 ± 24 182 ± 23 CB2 (3.36x) JWH-316 Phenylacetylindole 2862 ± 670 781 ± 105 CB2 (3.66x) JWH-336 Dibenzopyran 4589 ± 367 153 ± 15 CB2 (30x) JWH-338 Dibenzopyran >10000 111 ± 16 CB2 (>90x) JWH-339 Dibenzopyran >10000 2317 ± 93 CB2 (>4.3x) JWH-340 Dibenzopyran 135 ± 6 30 ± 1 CB2 (4.5x) JWH-341 Dibenzopyran 100 ± 8 10 ± 0.1 CB2 (10x) JWH-346 Naphthoylpyrrole 67 ± 6 39 ± 2 CB2 (1.72x) JWH-347 Naphthoylpyrrole 333 ± 17 169 ± 17 CB2 (1.97x) JWH-348 Naphthoylpyrrole 218 ± 19 53 ± 1 CB2 (4.11x) JWH-349 Dibenzopyran 376 ± 1 38 ± 4 CB2 (9.9x) JWH-350 Dibenzopyran 395 ± 50 12 ± 1 CB2 (33x) JWH-351 Dibenzopyran >10000 295 ± 3 CB2 (>34x) JWH-352 Dibenzopyran >10000 47 ± 2 CB2 (>213x) JWH-353 Dibenzopyran 1493 ± 10 31 ± 1 CB2 (48x) JWH-354 Dibenzopyran 1961 ± 21 241 ± 14 CB2 (8.1x) JWH-355 Dibenzopyran 2162 ± 220 108 ± 17 CB2 (20x) JWH-356 Dibenzopyran 5837 ± 701 108 ± 17 CB2 (54x) JWH-357 Dibenzopyran 647 ± 78 185 ± 4 CB2 (3.5x) JWH-358 Dibenzopyran 1243 ± 266 52 ± 3 CB2 (24x) JWH-359 Dibenzopyran 2918 ± 450 13.0 ± 0.2 CB2 (220x) JWH-360 Dibenzopyran 2449 ± 606 160 ± 8 CB2 (15x) JWH-361 Dibenzopyran 63 ± 3 2.7 ± 0.1 CB2 (23x) JWH-362 Dibenzopyran 127 ± 8 34 ± 5 CB2 (3.7x) JWH-363 Naphthoylpyrrole 245 ± 5 71 ± 1 CB2 (3.45x) JWH-364 Naphthoylpyrrole 34 ± 3 29 ± 1 CB2 (1.17x) JWH-365 Naphthoylpyrrole 17 ± 1 3.4 ± 0.2 CB2 (5.0x) JWH-366 Naphthoylpyrrole 191 ± 12 24 ± 1 CB2 (7.96x) JWH-367 Naphthoylpyrrole 53 ± 2 23 ± 1 CB2 (2.30x) JWH-368 Naphthoylpyrrole 16 ± 1 9.1 ± 0.7 CB2 (1.76x) JWH-369 Naphthoylpyrrole 7.9 ± 0.4 5.2 ± 0.3 CB2 (1.52x) JWH-370 Naphthoylpyrrole 5.6 ± 0.4 4.0 ± 0.5 CB2 (1.40x) JWH-371 Naphthoylpyrrole 42 ± 1 64 ± 2 CB1 (1.52x) JWH-372 Naphthoylpyrrole 77 ± 2 8.2 ± 0.2 CB1 (9.39x) JWH-373 Naphthoylpyrrole 60 ± 3 69 ± 2 CB1 (1.15x) JWH-387 Naphthoylindole 1.2 ± 0.1 1.1 ± 0.1 — JWH-398 Naphthoylindole 2.3 ± 0.1 2.8 ± 0.2 CB1 (1.22x) JWH-416 Naphthoylindole 73 ± 10 3.3 ± 0.1 CB2 (22x) JWH-417 Naphthoylindole 522 ± 58 13 ± 0.2 CB2 (40x) JWH-422 Naphthoylindole 501 ± 48 20 ± 0.4 CB2 (25x) JWH-423 Naphthoylindole 140 ± 10 6.6 ± 0.2 CB2 (21x) JWH-424 Naphthoylindole 21 ± 3.4 5.4 ± 0.2 CB2 (3.9x) JWH-425 Naphthoylindole 54 ± 11 10 ± 0.4 CB2 (5.4x)
See also List of AM cannabinoids List of CP cannabinoids List of HU cannabinoids List of miscellaneous designer cannabinoids
Notes
References