William Hussey may refer to:
Politicians William Hussey (MP for Stamford) (died 1531), MP for Stamford William Hussey (died 1556), MP for Grantham William Hussey (died 1570) (1524–1570), MP for Scarborough William Hussey (English diplomat) (1642–1691), English ambassador to the Ottoman Empire William Hussey (died 1813) (1725–1813), MP for Hindon, Salisbury and St Germans
Others William Hussey (astronomer) (1862–1926), American astronomer William Hussey (judge) (1443–1495), English Chief Justice William Hussey (writer), English children's author William Clive Hussey (1858–1923), British Army officer
See also William H. Huse (died 1888), American newspaper publisher and politician