St. Luke's General Hospital () is a public hospital located in Kilkenny, County Kilkenny, Ireland. It is 2 km north of the city centre, on the R693 road. The hospital is managed by Ireland East Hospital Group.

History The hospital was opened as Kilkenny County Hospital on 18 December 1941. New facilities, including a new accident & emergency department, acute medical assessment unit, day services unit and education centre were completed in 2016.

Services The hospital provides 285 beds, of which 228 are in-patient acute beds, while 12 are reserved for day cases. A further 45 beds are designated for in-patient psychiatric care.

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