Semenogelin is a protein that is involved in the formation of a gel matrix that encases ejaculated spermatozoa, preventing capacitation. It blocks capacitation mainly via inhibition of reactive oxygen species (ROS) generation.
Proteolysis by prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely.Entrez Gene: SEMG2 semenogelin II The cleavage products of the semenogelins constitute the main antibacterial components in human seminal plasma.
There are two variants of the semenogelin protein: semenogelin 1 and semenogelin 2.
Semenogelin along with prostate-specific antigen, are commonly tested for during crime scene investigation.
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