Ledford may refer to:
People Brandy Ledford (born 1969), American actress, model and Penthouse magazine's 1992 "Pet of the Year" Cawood Ledford (1926–2001), radio play-by-play announcer for the University of Kentucky Dwayne Ledford (born 1976), American football coach and former player Frank F. Ledford Jr. (1934–2019), American orthopedic surgeon Homer Ledford (1927–2006), instrument maker and bluegrass musician from Kentucky John Ledford (born 1969), American entrepreneur and producer Lily May Ledford (1917–1985), American clawhammer banjo and fiddle player Mark Ledford (1960–2004), American trumpeter, singer, and guitarist
Places Ledford Island, a site of the Mouse Creek phase archaeological culture of the Eastern Tennessee Ledford, Illinois, an unincorporated community in the Harrisburg Township, Saline County
Schools Ledford High School, a public high school in Thomasville, North Carolina Ledford Middle School, a public school in the Davidson County, North Carolina school district