Nepo may refer to:
Nepo, an orca captured in 1969 and featured in the 1977 film Orca Nepo (language), an Esperanto-based constructed language which served as a model for a Slavic version from 1915 called Neposlava A nickname for Ian Nepomniachtchi, Russian chess player A shortening of nepotism, as in the phrase "nepo baby" Nepovirus, genus of viruses