Melikyan or Melikian () is an Armenian surname. It may refer to:
Anna Melikian (born 1976), Russian-Armenian film and TV director, producer, and writer Arsen Melikyan (born 1976), Armenian weightlifter Hayk Melikyan (born 1980), Armenian pianist Papken Melikian (born 1960), Lebanese-Armenian footballer Romanos Melikian (1883–1935), Armenian composer Siouzana Melikián (born 1986), Mexican actress Sofya Melikyan (born 1978), Armenian pianist Souren Melikian (born 1936), French-Iranian art historian, art critic, and curator Yegishe Melikyan (born 1979), Armenian footballer
See also Melikian-Ouzounian School (1921–1953) in Cyprus, founded by the Melikyan family Melikov, the Russified version of Melikyan