Upton House may refer to:
Buildings Australia Home of pioneering Clifton family in Australind, Western Australia
United Kingdom Upton House, Warwickshire, a country house built c.1695, in the care of the National Trust Upton House, Dorset, a country house built in 1816 Upton House, Newham, a building in the London borough of Newham, birthplace of the surgeon Joseph Lister Ham House (Newham), London, known as Upton House until the late 1780s
United States George B. Upton House, Wickenburg, Arizona, listed on the National Register of Historic Places (NRHP) in Maricopa County, Arizona Upton (Baltimore, Maryland), a house listed on the NRHP Blanchard-Upton House, Andover, Massachusetts, NRHP-listed William Upton House, Sterling Heights, Michigan, also known as Upton House, NRHP-listed Harriet Taylor Upton House, Warren, Ohio, NRHP-listed
See also Clark Monroe's Uptown House, Harlem, New York NY was a jazz club and bar, one of the Cradles of Bebop Upton Apartments, Ogden, Utah, US, listed on the NRHP in Weber County, Utah Upton (disambiguation) Upton Park (disambiguation)