Mastronardi is a surname of Italian origin. Notable people with the surname include:
Alessandra Mastronardi (born 1986), Italian actress Bart Mastronardi (born 1972), American director, screenwriter, cinematographer and producer Carlos Mastronardi (1901–1976), Argentine journalist, poet, and translator Horace Mastronardi, Swiss lawyer who tried to have the Jaccoud case verdict overturned Rino Mastronardi (born 1969), Italian racing driver