Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.
It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).
The function of this protein is unknown at this time.
Protein sequence
1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 301 FMSLFIRNGN REILLETPAP
Homology
ARMCX6 is conserved in many eukaryotic organisms.
Orthologs
taxonomic name common name NCBI entry Percentage of sequence similarity Length (AAs) comments Homo sapiensHuman100%300 armadillo repeat containing X-linked 6 Macaca mulattaRhesus monkey97.0%300 PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1 Equus caballusHorse 90.0%300PREDICTED: similar to armadillo repeat containing, X-linked 6 Danio reriozebrafish84.0%301Similar to RIKEN cDNA 0610039K22 Mus musculusHouse Mouse97.7%393armadillo repeat containing, X-linked 6 (H. sapiens)-like Bos tauruscow83.0%301armadillo repeat containing, X-linked 6 Mus musculusMouse82.0%301armadillo repeat containing, X-linked 6 Takifugu rubripesTetradontoidea66.0%818aryl hydrocarbon receptor 2C Caenorhabditis elegansC. elegans50.0%332Serpentine Receptor, class H family member (srh-216) Saccharomyces cerevisiaeYeast70.0%910Hul5p Gallus gallusChicken52.0%317PREDICTED: hypothetical protein
Secondary Structure The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.SDSC Biology Workbench 2.0 10 20 30 40 ....*....|....*....|....*....|....*....|....*.. ARMCX6 231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277 1DW9_A 19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65 + + ++ + + + + + + + + + + ++++
Expression Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.EST Profile Viewer- HumanEST Profile Viewer- Mouse
References
External links
Further reading