Dark Zone may refer to:
Dark Zone, a universe in the Lexx television series Dark Zone, a concept in the Futari wa Pretty Cure anime series The Dark Zone, the Quake map (DM6) setting of the 1996 film Diary of a Camper Dark Zones, concepts in the video game Tom Clancy's The Division "Dark Zone", an episode of the History Channel show Shadow Force Dark Zone, a 2011 novel by Yusuke Kishi In immunology, the proliferative compartment of the germinal center reaction