Defending champion Venus Williams defeated her sister Serena Williams in the final, 6–1, 4–6, 6–4 to win the women's singles tennis title at the 1999 Miami Open. It was the pair's first meeting in a tournament final.
Seeds
All seeds received a bye to the second round.
Draw
Finals
Top half
Section 1
Section 2
Section 3
Section 4
Bottom half
Section 5
Section 6
Section 7
Section 8
Qualifying
Seeds
Qualifiers
Lucky losers Christína Papadáki
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
References 1999 Lipton Championships Draw