The 2010 NCAA Division I baseball season play of college baseball in the United States, organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began on February 19, 2010. The season progressed through the regular season, many conference tournaments and championship series, and concluded with the 2010 NCAA Division I baseball tournament and 2010 College World Series. The College World Series, which consisted of the eight remaining teams in the NCAA tournament, was held in its annual location of Omaha, Nebraska. It was the final College World Series held at Omaha's Rosenblatt Stadium, which closed following the event. It concluded on June 30, 2010, with the final game of the best of three championship series. South Carolina defeated UCLA two games to none to claim their first championship, which was also South Carolina's first national championship in any men's sport.

Realignment

New programs Seattle added a varsity intercollegiate baseball program for the 2010 season.

Dropped programs Both Northern Iowa and Vermont dropped their varsity intercollegiate baseball programs following the 2009 season.

Conference changes

Eight former Division I independents formed the new Great West Conference, whose champion would not qualify for the NCAA tournament. The eight schools that formed the conference were Chicago State, Houston Baptist, NJIT, North Dakota, Northern Colorado, NYIT, Texas–Pan American, and Utah Valley.

The Northeast Conference added Bryant, a former Division II member that had been an independent in 2009.

The Missouri Valley Conference, which lost Northern Iowa when it dropped its program, and the America East Conference, which lost Vermont when it dropped its program, each lost one member.

Conference formats The Southland Conference eliminated the divisional format it had used from 2008–2009.

Preseason The Texas Longhorns, defeated by LSU in the 2009 CWS championship series, entered the season ranked #1 in the major polls. Defending national champions LSU received a #2 ranking in the preseason.

Conference standings