McNichols is a surname. Notable people with the surname include:
Jeremy McNichols (born 1995), American football player John J. McNichols (1927–2020), American politician and lawyer John P. McNichols (1875–1932), American Jesuit priest Raymond Clyne McNichols (1914–1985), United States federal judge Robert James McNichols (1922–1993), United States federal judge Stephen McNichols (1914–1997), American politician, governor of Colorado Walter McNichols (1863–1924), American politician and businessman William Hart McNichols (born 1949), American Roman Catholic priest and artist William H. McNichols Jr. (1910–1997), American politician
See also McNichols Sports Arena ("Big Mac"), indoor arena in Denver, Colorado, USA