Husam al-Din or Husam ad-Din () is a masculine given name and surname of Arabic origin. Notable people with the name include:
Given name Hassam-ud-Din Rashidi (1911–1982), Pakistani journalist Husam al-Din Chalabi (1225–1284), Kurdish Sufi Husam al-Din Choban, commander and bey in the Sultanate of Rum Husam Uddin Chowdhury Fultali (born 1974), Bangladeshi Islamic scholar and author Husam al-Din Abu'l-Hayja (died 1197), Kurdish general Hussam ad-Din Jarallah (1884–1954), Grand Mufti of Jerusalem Hussam al-Din al-Jarrahi (died 1202), Ayyubid doctor, physician of Saladin Husam ad-Din Manikpuri, Indian Islamic scholar Husam al-Din Qaraja, governor of Sivas in the Seljuk Sultanate of Rum Husam al-Din Timurtash (1105–1154), Artuqid emir of Mardin and ruler of Aleppo Hüsamettin Böke (1910–1995), Turkish footballer Hüsamettin Cindoruk (1933–2026), Turkish politician Hüsamettin Özkan (born 1950), Turkish politician Hüsamettin Tut (born 1991), Turkish footballer
Surname al-Malik al-Mansour Hossam ad-Din Lajin al-Mansuri (died 1299), Sultan of Egypt al-Husayn Husam al-Din (died 1527), leader of the Tayyibi Isma'ili community
See also Sayf al-Din (disambiguation)