Spalletti is a surname. Notable people with the surname include:
Ettore Spalletti (1940–2019), Italian artist Gabriella Rasponi Spalletti (1853–1931), Italian feminist, educator and philanthropist Luciano Spalletti (born 1959), Italian footballer and football manager
See also Palazzo Spalletti-Trivelli, in the center of Reggio Emilia, Emilia Romagna, Italy