Francis Radclyffe may refer to:

Francis Radclyffe, 1st Earl of Derwentwater and 3rd Baronet (1625–1697) Sir Francis Radclyffe, 1st Baronet of the Radclyffe Baronets, of Derwentwater

See also Frances Radclyffe (disambiguation) for the female version of the name Francis Ratcliffe, zoologist