SGC may refer to:

Science and technology Satellite ground station Server-Gated Cryptography Soluble guanylate cyclase (sGC) Standard Geographical Classification code (Canada) Structural Genomics Consortium Salivary gland carcinoma, a type of oral cancer Swan-Ganz catheter, a type of pulmonary artery catheter

People and job titles Swiss Gaming Crew, a new E-Sports Team from League of Legends Secretary-General of the Council of the European Union, head of the General Secretariat of the Council Stephen Grover Cleveland, 22nd and 24th President of the United States

Entertainment Sega Genesis Collection SGC (wine) Sonic Gems Collection Southern Gospel Choir Stargate Command ScrewAttack Gaming Convention SGC Records (Screen Gems-Columbia) a subsidiary of Atlantic Records that distributed the Nazz