The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.
Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity.
List of hydrazine antidepressants
Marketed
Benmoxin (Neuralex, Nerusil) ‡ Iproclozide (Sursum) ‡ Iproniazid (Marsilid) ‡ Isocarboxazid (Marplan) Mebanazine (Actomol) ‡ Nialamide (Niamid) ‡ Octamoxin (Ximaol, Nimaol) ‡ Phenelzine (Nardil) Pheniprazine (Catron) ‡ Phenoxypropazine (Drazine) ‡ Pivhydrazine (Tersavid) ‡ Safrazine (Safra) ‡
Legend: ‡ = Withdrawn from the market; † = Partially discontinued; Bolded names indicate major drugs. Never marketed Carbenzide Cimemoxin Domoxin Metfendrazine Parkinson's Carbidopa Tranquillosedative Centazolone
References