Edward, Ed, Eddie or Ted O'Brien may refer to:
Ed O'Brien (born 1968), guitarist for Radiohead Sir Edward O'Brien, 2nd Baronet (1705–1765), Irish politician and baronet Edward Dominic O'Brien (1735–1801), Irish law enforcement official and British Army officer Sir Edward O'Brien, 4th Baronet (1773–1837), Irish politician and baronet Edward O'Brien, 14th Baron Inchiquin (1839–1900), Irish peer Edward Joseph Harrington O'Brien (1890–1941), American writer, poet, editor and anthologist Edward O'Brien (mural artist) (1910–1975), American artist and muralist Edward O'Brien (athlete) (1914–1976), American 400m runner Edward O'Brien (Irish republican) (1974–1996), IRA member Edward Conor Marshall O'Brien (1880–1952), Irish aristocrat, architect and sailor Eddie O'Brien (baseball) (1930–2014), American former Major League Baseball player Eddie O'Brien (hurler) (born 1945), Irish hurler Eddie O'Brien (footballer) (1883–1934), Australian rules footballer Ted O'Brien, Australian politician (born 1974) Ted O'Brien (American politician) (born 1957)
See also Edward O'Bryen (c. 1753–1808), sometimes O'Brien, Royal Navy admiral Edmond O'Brien (1915–1985), American actor and director