Clohessy is a surname. The name itself is an anglicized form of the Gaelic "Ó Clochasaigh," derived from the Gaelic word "cloch" meaning "stone."

Notable people with the surname include:

David Clohessy (born c. 1956), once-Roman Catholic American activist Paddy Clohessy (1908–1971), Irish sportsperson and Fianna Fáil politician Peadar Clohessy (1933–2014), Irish Fianna Fáil and Progressive Democrats politician Peter Clohessy (born 1966), Irish rugby union footballer Robert Clohessy (born 1958), American actor, played Sean Murphy on the HBO drama Oz Seán Clohessy (1931–2019), Irish hurler Sean Clohessy (born 1986), English professional footballer for Conference side Salisbury City