TSC may refer to:

Organizations Taiwan Semiconductor Company Limited, a Taiwanese semiconductor company Technology Service Corporation, a US engineering company Terrorist Screening Center, a division of the National Security Branch of the US Federal Bureau of Investigation The Shopping Channel, a Canadian television network The Soufan Center, an independent research center on global security matters The Support Center, in Durham, North Carolina, US Tractor Supply Company, a US farm supply and home-improvement retail chain The Spaceship Company, a British/American spaceship manufacturing company Technical Systems Consultants, a defunct supplier of software for SWTPC computers Temporary Slavery Commission, abolitionist organization at the League of Nations Teridian Semiconductor, a fabless semiconductor company in Irvine, California, US Air Transat (ICAO code), an airline based in Montreal, Canada The Transport Systems Catapult, which in April 2019 became the Connected Places Catapult FK TSC, a Serbian association football club

Education Tallahassee State College, public college in Tallahassee, Florida, U.S. Teacher-Student Centre, University of Dhaka, Bangladesh Texas Southmost College, a community college in Brownsville, US Thebarton Senior College, a public school in Adelaide, Australia Time to Succeed Coalition, an education non-profit in Boston, US Training Ship Chanakya, a nautical science college in Mumbai, India The Scots College, a private school in Sydney, Australia Teachers Service Commission, a Kenyan organization that registers, employs, promotes and pays Kenyan teachers Trinidad State College, a public community college in Trinidad, Colorado

Science and technology Thiazide-sensitive Na-Cl cotransporter, a carrier protein inhibited by so-called thiazides Tuberous sclerosis complex, a rare genetic disorder Tuberous sclerosis protein, the associated protein Trans sodium crocetinate, an oxygen diffusion-enhancing compound Thyristor switched capacitor, a feature in some AC power transmission systems

Computing Time Stamp Counter, an internal clock present in the IA-32 architecture since the Pentium processor Terminal Services Client, software for remote control of Microsoft windows

Arts and entertainment Ten Silver Coins, a 2009 novel TV Setouchi, a TV station in Japan The Shopping Channel, a cable television network available in Canada Tech Support Comedy, a web-based community for tech support workers The Secret Circle (TV series), an American television series

Other uses The Standard Code of Parliamentary Procedure, a manual on US parliamentary law Texas State Cemetery, in Austin, Texas, US Total Sanitation Campaign, former name of a program in India Turkvision Song Contest, a song contest for countries and regions which are of Turkic-speaking or Turkic ethnicity.