Knucklehead or Knuckleheads may refer to:
Arts and entertainment Fictional characters Knucklehead, the mascot of the band Five Finger Death Punch Knucklehead Smiff, ventriloquist dummy of Paul Winchell Knucklehead, from The Pee-wee Herman Show stage show and the Pee-wee's Playhouse television series Knucklehead, in Battle Angel Alita Knuckleheads, nickname of The Three Stooges
Film and television Knucklehead (2010 film), an American comedy Knucklehead (2015 film), an American drama Knuckleheads, 2012 Canadian animated TV series
Gaming Knuckleheads, a 2008 platform game by Nitrome Knuckle Heads, a 1992 arcade game
Music Knucklehead (band), a Canadian punk rock group "Knucklehead", B-side of the 1967 single "Soul Finger" by Bar-Kays "Knucklehead", a 1976 song by Grover Washington Jr.
Other uses Knuckleheads Saloon, a music venue in Kansas City, Missouri, US Harley-Davidson Knucklehead engine
See also Knucklehedz, member of hip hop collective Hit Squad